Acetic Anhydride → HCID 178488339, compound

HRID 1695617Notes

Reaction equation

HRID 1695617 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[CH:9]([NH:12][C:13]3[O:14][CH2:15][C:16]4[CH:22]=[C:21]([NH2:23])[CH:20]=[CH:19][C:17]=4[N:18]=3)[CH2:10][O:11][C:7]=2[CH:6]=[CH:5][CH:4]=1.[C:24](OC(=O)C)(=[O:26])[CH3:25]>>[CH3:1][O:2][C:3]1[C:8]2[CH:9]([NH:12][C:13]3[O:14][CH2:15][C:16]4[CH:22]=[C:21]([NH:23][C:24](=[O:26])[CH3:25])[CH:20]=[CH:19][C:17]=4[N:18]=3)[CH2:10][O:11][C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 178488337HCID 178488337, compound

Product 1

HCID 178488339HCID 178488339, compoundYield 88.2%

Procedure

Prepared from rac-N2-(4-methoxy-2,3-dihydro-benzofuran-3-yl)-4H-benzo[d][1,3]oxazine-2,6-diamine (Example 6) (100 mg, 0.321 mmol) and acetic anhydride (60.7 ul, 0.642 mmol) according to the procedure described for Example 48. Obtained the title compound as a white solid (100 mg, 88%), MS (ISP) m/e=354.2 [(M+H)+].

Sources & evidence

ORD record
ord-77a9244a3458402796370805071d4c57
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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