Acetic Anhydride → HCID 178488338, compound

HRID 1695618Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[CH:10]([NH:12][C:13]1[O:14][CH2:15][C:16]3[CH:22]=[C:21]([NH2:23])[CH:20]=[CH:19][C:17]=3[N:18]=1)[CH2:9][CH2:8]2.[C:24](OC(=O)C)(=[O:26])[CH3:25]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[CH:10]([NH:12][C:13]1[O:14][CH2:15][C:16]3[CH:22]=[C:21]([NH:23][C:24](=[O:26])[CH3:25])[CH:20]=[CH:19][C:17]=3[N:18]=1)[CH2:9][CH2:8]2

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 178488335HCID 178488335, compound

Product 1

HCID 178488338HCID 178488338, compoundYield 97%

Procedure

Prepared from rac-N2-(7-methoxy-indan-1-yl)-4H-benzo[d][1,3]oxazine-2,6-diamine (Example 10) (100 mg, 0.323 mmol) and acetic anhydride (61.1 ul, 0.646 mmol) according to the procedure described for Example 48. Obtained the title compound as a light brown foam (110 mg, 97%), MS (ISP) m/e=352.2 [(M+H)+].

Sources & evidence

ORD record: ord-dff4b4ba18654db187a88a7177db0a06
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163740B2

Reaction notes

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