5-Fluoro-2,3-dihydro-1H-inden-1-amine → HCID 178505421, compound

HRID 1695619Notes

Reaction equation

HRID 1695619 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:17]=[C:18]=S)=[C:6]([CH:16]=1)[CH2:7][O:8][Si](C(C)(C)C)(C)C.[F:20][C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[CH:26]([NH2:30])[CH2:25][CH2:24]2>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:17]=[C:18]([NH:30][CH:26]3[C:27]4[C:23](=[CH:22][C:21]([F:20])=[CH:29][CH:28]=4)[CH2:24][CH2:25]3)[O:8][CH2:7][C:6]=2[CH:16]=1

Participants

3

Reactant 2

HCID 166663285-Fluoro-2,3-dihydro-1H-inden-1-amineHCID 87311762(5-Bromo-2-isothiocyanato-benzyloxy)-tert-butyl-dimethyl-silane

Product 1

HCID 178505421HCID 178505421, compoundYield 69%

Procedure

Prepared from (5-bromo-2-isothiocyanato-benzyloxy)-tert-butyl-dimethyl-silane (Example 32, step B) (4.0 g, 11.2 mmol) and rac-5-fluoro-indan-1-ylamine (CAS 148960-33-2) (1.69 mg, 11.2 mmol) according to the procedure described for Example 1. Obtained the title compound as a light brown oil (2.77 g, 69%), MS (ISP) m/e=361.1 [(M+H)+].

Sources & evidence

ORD record
ord-c2b7ed34aae443f6894374b92fa57718
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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