Morpholine → HCID 178488348, compound

HRID 1695622Notes

Reaction equation

HRID 1695622 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:27]=[CH:26][C:9]2[N:10]=[C:11]([NH:14][CH:15]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][C:22]=4[O:24][CH3:25])[CH2:17][CH2:16]3)[O:12][CH2:13][C:8]=2[CH:7]=1)=[O:4].[NH:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>C(#N)C>[CH3:25][O:24][C:22]1[CH:21]=[CH:20][CH:19]=[C:18]2[C:23]=1[CH:15]([NH:14][C:11]1[O:12][CH2:13][C:8]3[CH:7]=[C:6]([NH:5][C:3](=[O:4])[CH2:2][N:28]4[CH2:33][CH2:32][O:31][CH2:30][CH2:29]4)[CH:27]=[CH:26][C:9]=3[N:10]=1)[CH2:16][CH2:17]2

Participants

4

Reactant 2

HCID 8083MorpholineHCID 178488342HCID 178488342, compound

Product 1

HCID 178488348HCID 178488348, compoundYield 97.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared from the above described rac-2-chloro-N-[2-(7-methoxy-indan-1-ylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide (100 mg, 0.259 mmol) and morpholine (226 ul, 2.59 mmol) in acetonitrile (1 ml) according to the procedure described for Example 3 step B. Obtained the title compound as an off-white foam (110 mg, 97%), MS (ISP) m/e=437.2 [(M+H)+].

Workup

  1. customPrepared from the

Sources & evidence

ORD record
ord-49cbdaded86a40ae909280ecd5fe6464
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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