2-Amino-4-(trifluoromethyl)pyrimidine → HCID 178488333, compound

HRID 1695627Notes

Reaction equation

HRID 1695627 reaction equation
Br[C:2]1[CH:23]=[CH:22][C:5]2[N:6]=[C:7]([NH:10][CH:11]3[C:15]4[C:16]([O:20][CH3:21])=[CH:17][CH:18]=[CH:19][C:14]=4[O:13][CH2:12]3)[O:8][CH2:9][C:4]=2[CH:3]=1.[NH2:24][C:25]1[N:30]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:28]=[CH:27][N:26]=1>>[CH3:21][O:20][C:16]1[C:15]2[CH:11]([NH:10][C:7]3[O:8][CH2:9][C:4]4[CH:3]=[C:2]([NH:24][C:25]5[N:30]=[C:29]([C:31]([F:34])([F:32])[F:33])[CH:28]=[CH:27][N:26]=5)[CH:23]=[CH:22][C:5]=4[N:6]=3)[CH2:12][O:13][C:14]=2[CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 5959152-Amino-4-(trifluoromethyl)pyrimidineHCID 178488327HCID 178488327, compound

Product 1

HCID 178488333HCID 178488333, compoundYield 59%

Procedure

The title compound (135 mg, 59%), yellow foam, MS (ISP): m/e=458.2 (M+H+), was prepared in accordance with the general method of Example 35 from rac-(6-bromo-4H-benzo[d][1,3]oxazin-2-yl)-(4-methoxy-2,3-dihydro-benzofuran-3-yl)-amine (example 54) (188 mg, 0.5 mmol) and commercially available 2-amino-4-trifluoromethyl-pyrimidine (163 mg, 1.0 mmol).

Sources & evidence

ORD record
ord-7480650fa2d6419086c47b3798fd6bcb
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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