2-Propanol, 1-amino-2-methyl- → HCID 178459316, compound

HRID 1695633Notes

Reaction equation

HRID 1695633 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:25]=[CH:24][C:9]2[N:10]=[C:11]([NH:14][C@H:15]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH2:17][CH2:16]3)[O:12][CH2:13][C:8]=2[CH:7]=1)=[O:4].[NH2:26][CH2:27][C:28]([CH3:31])([OH:30])[CH3:29]>C(#N)C>[OH:30][C:28]([CH3:31])([CH3:29])[CH2:27][NH:26][CH2:2][C:3]([NH:5][C:6]1[CH:25]=[CH:24][C:9]2[N:10]=[C:11]([NH:14][C@H:15]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH2:17][CH2:16]3)[O:12][CH2:13][C:8]=2[CH:7]=1)=[O:4]

Participants

4

Reactant 2

HCID 951022-Propanol, 1-amino-2-methyl-HCID 178520800HCID 178520800, compound

Product 1

HCID 178459316HCID 178459316, compoundYield 52.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared from 2-chloro-N-[2-((R)-indan-1-ylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide (Example 3 step A) (100 mg, 0.281 mmol) and 1-amino-2-methyl-propan-2-ol (126 mg, 1.405 mmol) in acetonitrile (1 ml) according to the procedure described for Example 3 step B. Obtained the title compound as a white solid (60 mg, 52%), MS (ISP) m/e=409.3 [(M+H)+].

Sources & evidence

ORD record
ord-2d1b56b92d864e2eb329ad504c2a1d55
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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