7-Methoxy-2,3-dihydro-1H-inden-1-amine → 6-bromo-N-(7-methoxy-2,3-dihydro-1H-inden-1-yl)-4H-3,1-benzoxazin-2-amine

HRID 1695638노트

반응식

HRID 1695638 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:17]=[C:18]=S)=[C:6]([CH:16]=1)[CH2:7][O:8][Si](C(C)(C)C)(C)C.[CH3:20][O:21][C:22]1[CH:23]=[CH:24][CH:25]=[C:26]2[C:30]=1[CH:29]([NH2:31])[CH2:28][CH2:27]2>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:17]=[C:18]([NH:31][CH:29]3[C:30]4[C:26](=[CH:25][CH:24]=[CH:23][C:22]=4[O:21][CH3:20])[CH2:27][CH2:28]3)[O:8][CH2:7][C:6]=2[CH:16]=1

참가 물질

3

반응물 2

HCID 186198817-Methoxy-2,3-dihydro-1H-inden-1-amineHCID 87311762(5-Bromo-2-isothiocyanato-benzyloxy)-tert-butyl-dimethyl-silane

생성물 1

HCID 1784883266-bromo-N-(7-methoxy-2,3-dihydro-1H-inden-1-yl)-4H-3,1-benzoxazin-2-amine수율 67%

실험 절차

Prepared from (5-bromo-2-isothiocyanato-benzyloxy)-tert-butyl-dimethyl-silane (Example 32, step B) (4.0 g, 11.2 mmol) and the rac-7-methoxy-indan-1-ylamine (Example 10, step A) (1.82 g, 11.2 mmol) according to the procedure described for Example 1. Obtained the title compound as a white solid (2.79 g, 67%), m.p. 151° C.; MS (ISP) m/e=375.1 [(M+H)+].

출처 및 근거

ORD 기록
ord-3de35a78c1a74221bc5448223cb44f56
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163740B2

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