7-Methoxy-2,3-dihydro-1H-inden-1-amine → 6-bromo-N-(7-methoxy-2,3-dihydro-1H-inden-1-yl)-4H-3,1-benzoxazin-2-amine

Participants

Reaction Steps

Prepared from (5-bromo-2-isothiocyanato-benzyloxy)-tert-butyl-dimethyl-silane (Example 32, step B) (4.0 g, 11.2 mmol) and the rac-7-methoxy-indan-1-ylamine (Example 10, step A) (1.82 g, 11.2 mmol) according to the procedure described for Example 1. Obtained the title compound as a white solid (2.79 g, 67%), m.p. 151° C.; MS (ISP) m/e=375.1 [(M+H)+].

Provenance & Evidence