2-Amino-6-(trifluoromethyl)pyridine → HCID 178488330, compound

HRID 1695641Notes

Reaction equation

HRID 1695641 reaction equation
Br[C:2]1[CH:23]=[CH:22][C:5]2[N:6]=[C:7]([NH:10][CH:11]3[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][C:18]=4[O:20][CH3:21])[CH2:13][CH2:12]3)[O:8][CH2:9][C:4]=2[CH:3]=1.[NH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:33])[F:32])[N:26]=1>>[CH3:21][O:20][C:18]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:19]=1[CH:11]([NH:10][C:7]1[O:8][CH2:9][C:4]3[CH:3]=[C:2]([NH:24][C:25]4[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:33])([F:32])[F:34])[N:26]=4)[CH:23]=[CH:22][C:5]=3[N:6]=1)[CH2:12][CH2:13]2

Participants

3

Reactant 2

HCID 8210242-Amino-6-(trifluoromethyl)pyridineHCID 1784883266-bromo-N-(7-methoxy-2,3-dihydro-1H-inden-1-yl)-4H-3,1-benzoxazin-2-amine

Product 1

HCID 178488330HCID 178488330, compoundYield 63.4%

Procedure

The title compound (144 mg, 63%), light brown foam, MS (ISP): m/e=455.3 (M+H+), was prepared in accordance with the general method of Example 35 from rac-(6-bromo-4H- benzo[d][1,3]oxazin-2-yl)-(7-methoxy-indan-1-yl)-amine (Example 74) (187 mg, 0.5 mmol) an commercially available 2-amino-6-trifluoromethyl-pyridine (162 mg, 1.0 mmol).

Sources & evidence

ORD record
ord-85eaa9055aa94704b196f69d99f407be
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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