2-Amino-4-(trifluoromethyl)pyrimidine → HCID 178488332, compound

HRID 1695642Notes

Reaction equation

HRID 1695642 reaction equation
Br[C:2]1[CH:23]=[CH:22][C:5]2[N:6]=[C:7]([NH:10][CH:11]3[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][C:18]=4[O:20][CH3:21])[CH2:13][CH2:12]3)[O:8][CH2:9][C:4]=2[CH:3]=1.[NH2:24][C:25]1[N:30]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:28]=[CH:27][N:26]=1>>[CH3:21][O:20][C:18]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:19]=1[CH:11]([NH:10][C:7]1[O:8][CH2:9][C:4]3[CH:3]=[C:2]([NH:24][C:25]4[N:30]=[C:29]([C:31]([F:34])([F:32])[F:33])[CH:28]=[CH:27][N:26]=4)[CH:23]=[CH:22][C:5]=3[N:6]=1)[CH2:12][CH2:13]2

Participants

3

Reactant 2

HCID 5959152-Amino-4-(trifluoromethyl)pyrimidineHCID 1784883266-bromo-N-(7-methoxy-2,3-dihydro-1H-inden-1-yl)-4H-3,1-benzoxazin-2-amine

Product 1

HCID 178488332HCID 178488332, compoundYield 62%

Procedure

The title compound (141 mg, 62%), yellow foam, MS (ISP): m/e=456.3 (M+H+), was prepared in accordance with the general method of Example 35 from rac-(6-bromo-4H-benzo[d][1,3]oxazin-2-yl)-(7-methoxy-indan-1-yl)-amine (Example 74) (187 mg, 0.5 mmol) and commercially available 2-amino-4-trifluoromethyl-pyrimidine (163 mg, 1.0 mmol).

Sources & evidence

ORD record
ord-cf3394d5137e4716a4b159b11ff46b94
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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