1-Methylpiperazine → HCID 178425505, compound

HRID 1695643Notes

Reaction equation

HRID 1695643 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:23]=[CH:22][C:9]2[N:10]=[C:11]([NH:14][CH2:15][C:16]3[O:17][C:18]([CH3:21])=[CH:19][CH:20]=3)[O:12][CH2:13][C:8]=2[CH:7]=1)=[O:4].[CH3:24][N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>C(#N)C>[CH3:21][C:18]1[O:17][C:16]([CH2:15][NH:14][C:11]2[O:12][CH2:13][C:8]3[CH:7]=[C:6]([NH:5][C:3](=[O:4])[CH2:2][N:28]4[CH2:29][CH2:30][N:25]([CH3:24])[CH2:26][CH2:27]4)[CH:23]=[CH:22][C:9]=3[N:10]=2)=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 178425504HCID 178425504, compound

Product 1

HCID 178425505HCID 178425505, compoundYield 71.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared from the above described 2-chloro-N-{2-[(5-methyl-furan-2-ylmethyl)-amino]-4H-benzo[d][1,3]oxazin-6-yl}-acetamide (100 mg, 0.300 mmol) and 1-methylpiperazine (0.333 ml 2.996 mmol) in acetonitrile (1 ml) according to the procedure described for Example 3 step B. Obtained the title compound as an off-white foam (85 mg, 71%), MS (ISP) m/e=398.2 [(M+H)+].

Workup

  1. customPrepared from the

Sources & evidence

ORD record
ord-02b8a3133f574320b22bd8bcd54fcf48
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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