1-Methylpiperazine → HCID 178488344, compound

HRID 1695645Notes

Reaction equation

HRID 1695645 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:27]=[CH:26][C:9]2[N:10]=[C:11]([NH:14][CH:15]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][C:22]=4[O:24][CH3:25])[CH2:17][CH2:16]3)[O:12][CH2:13][C:8]=2[CH:7]=1)=[O:4].[CH3:28][N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>C(#N)C>[CH3:25][O:24][C:22]1[CH:21]=[CH:20][CH:19]=[C:18]2[C:23]=1[CH:15]([NH:14][C:11]1[O:12][CH2:13][C:8]3[CH:7]=[C:6]([NH:5][C:3](=[O:4])[CH2:2][N:32]4[CH2:33][CH2:34][N:29]([CH3:28])[CH2:30][CH2:31]4)[CH:27]=[CH:26][C:9]=3[N:10]=1)[CH2:16][CH2:17]2

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 178488342HCID 178488342, compound

Product 1

HCID 178488344HCID 178488344, compoundYield 77.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared from rac-2-chloro-N-[2-(7-methoxy-indan-1-ylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide (Example 55 step A) (100 mg, 0.259 mmol) and 1-methylpiperazine (0.289 ml 2.595 mmol) in acetonitrile (1 ml) according to the procedure described for Example 3 step B. Obtained the title compound as a light yellow foam (90 mg, 77%), MS (ISP) m/e=450.2 [(M+H)+].

Sources & evidence

ORD record
ord-1a6104edd8de465988c8ad74a21afbcd
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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