Benzenesulfonyl chloride → HCID 178527454, compound

HRID 1695655Notes

Reaction equation

[CH:1]1([NH:8][C:9]2[O:10][CH2:11][C:12]3[CH:18]=[C:17]([NH2:19])[CH:16]=[CH:15][C:13]=3[N:14]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:20]1([S:26](Cl)(=[O:28])=[O:27])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH:1]1([NH:8][C:9]2[O:10][CH2:11][C:12]3[CH:18]=[C:17]([NH:19][S:26]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)(=[O:28])=[O:27])[CH:16]=[CH:15][C:13]=3[N:14]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

Reactant 2

HCID 7369Benzenesulfonyl chloride

HCID 178507250HCID 178507250, compound

Product 1

HCID 178527454HCID 178527454, compoundYield 5.5%

Procedure

Prepared from N2-cycloheptyl-4H-benzo[d][1,3]oxazine-2,6-diamine (example 92) (200 mg, 0.77 mmol) and benzenesulfonyl chloride (136 mg, 0.77 mmol) according to the procedure described for example 27. Obtained the title compound as a white foam (17 mg, 5.5%), MS (ISP) m/e=400.3 [(M+H)+].

Sources & evidence

ORD record: ord-5294fe27bbc24faeaacb63e25d3faf3a
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163740B2

Reaction notes

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