1-Methylpiperazine → HCID 178480914, compound

HRID 1695671Notes

Reaction equation

HRID 1695671 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:26]=[CH:25][C:9]2[N:10]=[C:11]([NH:14][CH:15]3[C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[O:18][CH2:17][CH2:16]3)[O:12][CH2:13][C:8]=2[CH:7]=1)=[O:4].[CH3:27][N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[O:18]1[C:19]2[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:15]([NH:14][C:11]2[O:12][CH2:13][C:8]3[CH:7]=[C:6]([NH:5][C:3](=[O:4])[CH2:2][N:31]4[CH2:32][CH2:33][N:28]([CH3:27])[CH2:29][CH2:30]4)[CH:26]=[CH:25][C:9]=3[N:10]=2)[CH2:16][CH2:17]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 178520797HCID 178520797, compound

Product 1

HCID 178480914HCID 178480914, compoundYield 100.1%

Procedure

Prepared from the above described rac-2-chloro-N-[2-(chroman-4-ylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide (186 mg, 0.50 mmol; HPLC 1.092 min) and 1-methylpiperazine (1.1 ml, 10 mmol) according to the procedure described for Example 3 step B. Obtained the title compound as a white solid (218 mg, 100%; HPLC 0.413 min), MS (ISP) m/e=436.1 [(M+H)+].

Workup

  1. customPrepared from the

Sources & evidence

ORD record
ord-7226e3ab6c9744f2801b5044671aab48
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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