1-Methylpiperazine → HCID 178480916, compound

HRID 1695674Notes

Reaction equation

HRID 1695674 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:25]=[CH:24][C:9]2[N:10]=[C:11]([NH:14][CH2:15][CH2:16][O:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[O:12][CH2:13][C:8]=2[CH:7]=1)=[O:4].[CH3:26][N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[CH3:26][N:27]1[CH2:32][CH2:31][N:30]([CH2:2][C:3]([NH:5][C:6]2[CH:25]=[CH:24][C:9]3[N:10]=[C:11]([NH:14][CH2:15][CH2:16][O:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[O:12][CH2:13][C:8]=3[CH:7]=2)=[O:4])[CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 178520799HCID 178520799, compound

Product 1

HCID 178480916HCID 178480916, compoundYield 101.1%

Procedure

Prepared from the above described 2-chloro-N-[2-(2-phenoxy-ethylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide (180 mg, 0.50 mmol; HPLC 1.096 min) and 1-methylpiperazine (1.1 ml, 10 mmol) according to the procedure described for Example 3 step B. Obtained the title compound as a white foam (214 mg, 100%; HPLC 0.494 min), MS (ISP) m/e=424.1 [(M+H)+].

Workup

  1. customPrepared from the

Sources & evidence

ORD record
ord-c69e823b27f944cb865ba30c91c5b882
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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