Morpholine → HCID 178521232, compound

HRID 1695675Notes

Reaction equation

HRID 1695675 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:25]=[CH:24][C:9]2[N:10]=[C:11]([NH:14][CH2:15][CH2:16][O:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[O:12][CH2:13][C:8]=2[CH:7]=1)=[O:4].[NH:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[N:26]1([CH2:2][C:3]([NH:5][C:6]2[CH:25]=[CH:24][C:9]3[N:10]=[C:11]([NH:14][CH2:15][CH2:16][O:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[O:12][CH2:13][C:8]=3[CH:7]=2)=[O:4])[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 178520799HCID 178520799, compound

Product 1

HCID 178521232HCID 178521232, compoundYield 100.4%

Procedure

Prepared from 2-chloro-N-[2-(2-phenoxy-ethylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide (Example 122, step A) (180 mg, 0.50 mmol; HPLC 1.096 min) and morpholine (0.87 ml, 10 mmol) according to the procedure described for Example 3 step B. Obtained the title compound as a white solid (206 mg, 100%; HPLC 0.588 min), MS (ISP) m/e=411.2 [(M+H)+].

Sources & evidence

ORD record
ord-ec09a3bcf8ed413bbf46cb5e87f4d097
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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