Isopropyl isocyanate → HCID 59231782, compound

HRID 1695688Notes

Reaction equation

HRID 1695688 reaction equation
[CH3:1][C:2]1([CH3:23])[CH2:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([NH:11][C:12]3[O:13][CH2:14][C:15]4[CH:21]=[C:20]([NH2:22])[CH:19]=[CH:18][C:16]=4[N:17]=3)[C:4]=2[O:3]1.[CH:24]([N:27]=[C:28]=[O:29])([CH3:26])[CH3:25]>>[CH3:1][C:2]1([CH3:23])[CH2:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([NH:11][C:12]3[O:13][CH2:14][C:15]4[CH:21]=[C:20]([NH:22][C:28]([NH:27][CH:24]([CH3:26])[CH3:25])=[O:29])[CH:19]=[CH:18][C:16]=4[N:17]=3)[C:4]=2[O:3]1

Participants

3

Reactant 2

HCID 61277Isopropyl isocyanateHCID 86639787HCID 86639787, compound

Product 1

HCID 59231782HCID 59231782, compoundYield 68%

Procedure

Prepared from the above described N2-(2,2-dimethyl-2,3-dihydro-benzofuran-7-yl)-4H-benzo[d][1,3]oxazine-2,6-diamine (150 mg, 0.49 mmol) and isopropyl isocyanate (42 mg, 0.49 mmol) according to the procedure described for Example 16. Obtained the title compound as a white solid (131 mg, 68%), MS (ISP) m/e=395.3 [(M+H)+].

Workup

  1. customPrepared from the

Sources & evidence

ORD record
ord-4afe1dd929c44b53a4ed12e5904466dc
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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