Diisopropylethylamine → HCID 178494599, compound

HRID 1695691Notes

Reaction equation

HRID 1695691 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:27]=[CH:26][C:9]2[N:10]=[C:11]([NH:14][CH:15]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][C:22]=4[O:24][CH3:25])[CH2:17][CH2:16]3)[O:12][CH2:13][C:8]=2[CH:7]=1)=[O:4].[CH3:28][O:29][CH2:30][CH:31]1[CH2:36][NH:35][CH2:34][CH2:33][N:32]1[CH3:37].C(N(C(C)C)CC)(C)C>C(#N)C>[CH3:25][O:24][C:22]1[CH:21]=[CH:20][CH:19]=[C:18]2[C:23]=1[CH:15]([NH:14][C:11]1[O:12][CH2:13][C:8]3[CH:7]=[C:6]([NH:5][C:3](=[O:4])[CH2:2][N:35]4[CH2:34][CH2:33][N:32]([CH3:37])[CH:31]([CH2:30][O:29][CH3:28])[CH2:36]4)[CH:27]=[CH:26][C:9]=3[N:10]=1)[CH2:16][CH2:17]2

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 19777245HCID 19777245, compoundHCID 178488342HCID 178488342, compound

Product 1

HCID 178494599HCID 178494599, compoundYield 33%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared from rac-2-chloro-N-[2-(7-methoxy-indan-1-ylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide (Example 55, step A) (328 mg, 0.85 mmol), commercially available rac-2-methoxymethyl-1-methyl-piperazine (CAS no. 734507-92-7) (123 mg, 0.85 mmol) and diisopropylethyl amine (723 ul, 4.25 mmol) in acetonitrile (2 ml) according to the procedure described for Example 3 step B. Obtained the title compound as a white foam (137 mg, 33%), MS (ISP) m/e=494.3 [(M+H)+].

Sources & evidence

ORD record
ord-cfa25cec5e804abcbea03a85faaf6455
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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