Diisopropylethylamine → HCID 178494601, compound

HRID 1695692Notes

Reaction equation

HRID 1695692 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:25]=[CH:24][C:9]2[N:10]=[C:11]([NH:14][C@H:15]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH2:17][CH2:16]3)[O:12][CH2:13][C:8]=2[CH:7]=1)=[O:4].[CH3:26][O:27][CH2:28][CH:29]1[CH2:34][NH:33][CH2:32][CH2:31][N:30]1[CH3:35].C(N(C(C)C)CC)(C)C>C(#N)C>[C@H:15]1([NH:14][C:11]2[O:12][CH2:13][C:8]3[CH:7]=[C:6]([NH:5][C:3](=[O:4])[CH2:2][N:33]4[CH2:32][CH2:31][N:30]([CH3:35])[CH:29]([CH2:28][O:27][CH3:26])[CH2:34]4)[CH:25]=[CH:24][C:9]=3[N:10]=2)[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:17][CH2:16]1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 19777245HCID 19777245, compoundHCID 178520800HCID 178520800, compound

Product 1

HCID 178494601HCID 178494601, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared from 2-chloro-N-[2-((R)-indan-1-ylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide (Example 3, step A) (70 mg, 0.197 mmol), commercially available rac-2-methoxymethyl-1-methyl-piperazine (CAS no. 734507-92-7) (28.5 mg, 0.197 mmol) and diisopropylethyl amine (167 ul, 0.984 mmol) in acetonitrile (2 ml) according to the procedure described for Example 3 step B. Obtained the title compound as a light yellow (50 mg, 55%), MS (ISP) m/e=464.3 [(M+H)+].

Sources & evidence

ORD record
ord-cc9eed9db99b463e89268a3516d54945
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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