Cyclooctylamine → HCID 178526443, compound

HRID 1695697Notes

Reaction equation

C([Si]([O:8][CH2:9][C:10]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:11]=1[N:19]=[C:20]=S)(C)C)(C)(C)C.[CH:22]1([NH2:30])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>>[CH:22]1([NH:30][C:20]2[O:8][CH2:9][C:10]3[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:11]=3[N:19]=2)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1

Participants

Reactant 2

HCID 2903Cyclooctylamine

HCID 46855450tert-Butyl-(2-isothiocyanato-5-nitro-benzyloxy)-dimethyl-silane

Product 1

HCID 178526443HCID 178526443, compoundYield 87.9%

Procedure

Prepared from tert-butyl-(2-isothiocyanato-5-nitro-benzyloxy)-dimethyl-silane (Example C1) (4.0 g, 12 mmol) and cyclooctylamine (1.6 g, 12 mmol) according to the procedure described for Example 1. Obtained the title compound as a yellow viscous oil (3.2 g, 83%), MS (ISP) m/e=304.1 [(M+H)+].

Sources & evidence

ORD record: ord-ad38743bf8b543ffaf1d238c37f6fce5
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163740B2

Reaction notes

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