HCID 67278058, compound → HCID 67212627, compound

HRID 1695703Notes

Reaction equation

HRID 1695703 reaction equation
[C:1]1([S:7]([N:10]2[CH2:15][CH:14]([CH2:16][O:17][CH3:18])[N:13](CC3C=CC=CC=3)[CH:12]([CH2:26][O:27][CH3:28])[CH2:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)C.[Pd]>[C:1]1([S:7]([N:10]2[CH2:15][CH:14]([CH2:16][O:17][CH3:18])[NH:13][CH:12]([CH2:26][O:27][CH3:28])[CH2:11]2)(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 67278058HCID 67278058, compound

Product 1

HCID 67212627HCID 67212627, compoundYield 95.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of the above described (2SR,6SR)-4-benzenesulfonyl-1-benzyl-2,6-bis-methoxymethyl-piperazine (2.355 g, 5.82 mmol) in ethanol (300 ml) with 10% palladium on carbon (620 mg, 10 mol %) was hydrogenated at 50° C. for 2 h. The catalyst was filtered off, washed with ethanol, the filtrate was evaporated totally and dried in high vacuum to give the title compound as a white solid (1.74 g, 95%), MS (ISP) m/e=315.0 [(M+H)+].

Workup

  1. additionA mixture of the
  2. filtrationThe catalyst was filtered off
  3. washwashed with ethanol
  4. customthe filtrate was evaporated totally
  5. customdried in high vacuum

Sources & evidence

ORD record
ord-93e4746e22ce48b09773a7a0f8e1992d
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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