HCID 58255767, compound → HCID 58255762, compound

HRID 1695713Notes

Reaction equation

HRID 1695713 reaction equation
[N+:1]([C:4]1[C:5]2[C:9]([CH:10]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH:20]4[CH2:25][CH2:24][CH2:23][CH2:22][O:21]4)[CH:14]=3)[CH:12]=1)=[N:8][N:7]([CH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][O:27]1)[CH:6]=2)([O-])=O>C(OCC)(=O)C.[Pd]>[O:27]1[CH2:28][CH2:29][CH2:30][CH2:31][CH:26]1[N:7]1[CH:6]=[C:5]2[C:9]([CH:10]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH:20]4[CH2:25][CH2:24][CH2:23][CH2:22][O:21]4)[CH:14]=3)[CH:12]=[C:4]2[NH2:1])=[N:8]1

Participants

4

Reactant 1

HCID 58255767HCID 58255767, compound

Product 1

HCID 58255762HCID 58255762, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

4-Nitro-2-(tetrahydro-2H-pyran-2-yl)-6-[3-(tetrahydro-2H-pyran-2-yloxy)phenyl]-2H-indazole (1.06 g, 2.5 mmol) was dissolved in ethyl acetate (100 ml) and 10% Pd/C (53 mg) was added. The reaction was stirred under an atmosphere of hydrogen gas (1 atm) at RT for 16 h. The reaction mixture was filtered through celite and the solvent was removed in vacuo to yield the title compound, 828 mg, used without further purification.

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-61134e05c31b4ac78210b9d08ecee1e6
Source dataset
uspto-grants-2012_04
Patent number
US08163743B2

Reaction notes

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