HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → N-(6-Bromo-1H-indazol-4-yl)-2-pyridinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Picolinoyl Chloride Hydrochloride | HCID 135033 | — |
| Reactant | 6-Bromo-1H-indazol-4-amine | HCID 24728063 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(6-Bromo-1H-indazol-4-yl)-2-pyridinecarboxamide | HCID 58255852 | — |
Reaction Steps
6-Bromo-1H-indazol-4-amine (100 mg, 0.47 mmol), 2-pyridinecarbonyl chloride hydrochloride (100 mg, 0.56 mmol) and DIPEA (0.164 ml, 0.94 mmol) were stirred in DCM (10 ml) at RT overnight. The reaction was concentrated in vacuo. The residue was purified by MDAP (Method B) and appropriate fractions were evaporated to give the title compound, 38 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163743B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-942ef56db10c40e09c283f66ace3f07f |
| Source note | uspto-grants-2012_04 |