反应详情

3-Amino-5-bromo-2-chloropyridine (797 mg) in dry pyridine (10 ml) was treated with 5-fluoro-2-methylbenzenesulfonyl chloride (962 mg) then stirred at RT over the weekend. The reaction was purified by prep-HPLC. Desired fractions were concentrated under reduced pressure, diluted with saturated sodium bicarbonate (aq) and brine and extracted into DCM. The solvent was dried over magnesium sulfate, filtered then evaporated to give title compound (865 mg).

1. customThe reaction was purified by prep-HPLC
2. concentrationDesired fractions were concentrated under reduced pressure
3. additiondiluted with saturated sodium bicarbonate (aq) and brine
4. extractionextracted into DCM
5. dry with materialThe solvent was dried over magnesium sulfate
6. filtrationfiltered
7. customthen evaporated