5-Fluoro-2-methylbenzenesulphonyl chloride → N-(5-Bromo-2-chloro-3-pyridinyl)-5-fluoro-2-methylbenzenesulfonamide

Participants

Reaction Steps

3-Amino-5-bromo-2-chloropyridine (797 mg) in dry pyridine (10 ml) was treated with 5-fluoro-2-methylbenzenesulfonyl chloride (962 mg) then stirred at RT over the weekend. The reaction was purified by prep-HPLC. Desired fractions were concentrated under reduced pressure, diluted with saturated sodium bicarbonate (aq) and brine and extracted into DCM. The solvent was dried over magnesium sulfate, filtered then evaporated to give title compound (865 mg).

Provenance & Evidence