HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(5-bromopyridin-3-yl)benzenesulfonamide → N-{5-[4-Amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-3-pyridinyl}benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(5-bromopyridin-3-yl)benzenesulfonamide | HCID 57843412 | — |
| Reactant | 1-(phenylsulfonyl)-6-(trimethylstannanyl)-1H-indazol-4-amine | HCID 58255743 | — |
| Catalyst | HCID 178420574 | HCID 178420574 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-{5-[4-Amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-3-pyridinyl}benzenesulfonamide | HCID 58255758 | — |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
In a separate microwave vial, 1-(phenylsulfonyl)-6-(trimethylstannanyl)-1H-indazol-4-amine (50 mg), N-(5-bromo-3-pyridinyl)benzenesulfonamide (39.5 mg) and chloro[2′-(dimethylamino)-2-biphenylyl]palladium-(1R,4S)-bicyclo[2.2.1]hept-2-yl[(1S,4R)-bicyclo[2.2.1]hept-2-yl]phosphane (1:1) (6.4 mg) were dissolved in DMF (1 ml) and the reaction was heated under microwave irradiation for 15 min at 120° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163743B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-716912c306ff401d9bbad93d126d105c |
| Source note | uspto-grants-2012_04 |