HRID1695752

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57843412

N-(5-Bromopyridin-3-yl)benzenesulfonamide

C11H9BrN2O2S

结构：[CH3][Sn]([CH3])([CH3])[c]1cc(N)c2cnn(S(=O)(=O)c3ccccc3)c2c1

HCID58255743

未命名化合物

PRODUCTS

生成物

结构：Nc1cc(-c2cncc(NS(=O)(=O)c3ccccc3)c2)cc2c1cnn2S(=O)(=O)c1ccccc1

HCID58255758

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

结构：C1C[C@@H]2C[C@H]1CC2PC1C[C@@H]2CC[C@H]1C2.CN(C)c1ccccc1-c1ccccc1[Pd]Cl

催化剂HCID178420574

未命名化合物

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度: 120 °C

PROCEDURE

实验过程

In a separate microwave vial, 1-(phenylsulfonyl)-6-(trimethylstannanyl)-1H-indazol-4-amine (50 mg), N-(5-bromo-3-pyridinyl)benzenesulfonamide (39.5 mg) and chloro[2′-(dimethylamino)-2-biphenylyl]palladium-(1R,4S)-bicyclo[2.2.1]hept-2-yl[(1S,4R)-bicyclo[2.2.1]hept-2-yl]phosphane (1:1) (6.4 mg) were dissolved in DMF (1 ml) and the reaction was heated under microwave irradiation for 15 min at 120° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-716912c306ff401d9bbad93d126d105c
来源数据集: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08163743B2
来源说明: uspto-grants-2012_04

反应 SMILES

Br[C:2]1[CH:3]=[C:4]([NH:8][S:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)(=[O:11])=[O:10])[CH:5]=[N:6][CH:7]=1.[C:18]1([S:24]([N:27]2[C:35]3[CH:34]=[C:33]([Sn](C)(C)C)[CH:32]=[C:31]([NH2:40])[C:30]=3[CH:29]=[N:28]2)(=[O:26])=[O:25])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CN(C=O)C.Cl[Pd]C1C=CC=CC=1C1C=CC=CC=1N(C)C.[C@H]12C[C@H](CC1)CC2PC1C[C@H]2C[C@@H]1CC2>[NH2:40][C:31]1[CH:32]=[C:33]([C:2]2[CH:3]=[C:4]([NH:8][S:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)(=[O:11])=[O:10])[CH:5]=[N:6][CH:7]=2)[CH:34]=[C:35]2[C:30]=1[CH:29]=[N:28][N:27]2[S:24]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)(=[O:26])=[O:25]