反应详情

N-[5-(4-Amino-1-methyl-1H-indazol-6-yl)-2-chloro-3-pyridinyl]methanesulfonamide (75 mg) was dissolved in DCM (2 ml) and pyridine (0.052 ml) was added followed by 2-methyl-1,3-thiazole-4-carbonyl chloride (52 mg) in DCM (1 ml) as a suspension. The reaction was stirred at RT for 1 h. Saturated sodium bicarbonate solution was added followed by DCM (3 ml) and the reaction was stirred vigorously. The reaction was passed through a hydrophobic frit and evaporated to dryness. The residue was dissolved in DMSO:MeOH (1:1, v/v, 1 ml) and purified by MDAP (method E) to give the title compound (1.5 mg).

1. stirringthe reaction was stirred vigorously
2. customevaporated to dryness
3. dissolutionThe residue was dissolved in DMSO:MeOH (1:1, v/v, 1 ml)
4. custompurified by MDAP (method E)