反应详情

To a solution of ethyl 2-(3-isopentyl-4-oxo-2-phenylthiazolidin-5-ylidene)acetate (0.031 g, 0.1 mmol) and aq. NaOH (0.3 ml of 1 N) in MeOH was stirred at 40° C. for 2 hours. HCl (0.5 ml of 1 N) was added and the MeOH was evaporated. Water and EtOAc was added and the layers separated. The aqueous layer was extracted with EtOAc (2×), all organic layers were combined, dried (MgSO4) and evaporated to dryness to give the desired product as an orange oil (11 mg, 36%).

1. customthe MeOH was evaporated
2. additionWater and EtOAc was added
3. customthe layers separated
4. extractionThe aqueous layer was extracted with EtOAc (2×)
5. dry with materialdried (MgSO4)
6. customevaporated to dryness