反应详情

(2-(2-(piperidin-1-yl)ethylamino)-3-fluorophenyl)methanol (453 mg, 1.795 mmol) and MnO2 (692 mg, 7.960 mmol) were heated in toluene (15 mL) at reflux overnight. The suspension was filtered through Celite with CH2Cl2 and concentrated on a rotary evaporator. Crude 2-(2-(piperidin-1-yl)ethylamino)-3-fluorobenzaldehyde was carried on to the next reaction.

1. temperatureat reflux overnight
2. filtrationThe suspension was filtered through Celite with CH2Cl2
3. concentrationconcentrated on a rotary evaporator
4. customCrude 2-(2-(piperidin-1-yl)ethylamino)-3-fluorobenzaldehyde was carried on to the next reaction