HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-(2-(Piperidin-1-yl)ethylamino)-3-fluorophenyl)methanol → 2-(2-(Piperidin-1-yl)ethylamino)-3-fluorobenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-(2-(Piperidin-1-yl)ethylamino)-3-fluorophenyl)methanol | HCID 57774402 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(2-(Piperidin-1-yl)ethylamino)-3-fluorobenzaldehyde | HCID 57774413 | — |
Reaction Steps
(2-(2-(piperidin-1-yl)ethylamino)-3-fluorophenyl)methanol (453 mg, 1.795 mmol) and MnO2 (692 mg, 7.960 mmol) were heated in toluene (15 mL) at reflux overnight. The suspension was filtered through Celite with CH2Cl2 and concentrated on a rotary evaporator. Crude 2-(2-(piperidin-1-yl)ethylamino)-3-fluorobenzaldehyde was carried on to the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163737B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-86435a16b620414f925a41ddab357764 |
| Source note | uspto-grants-2012_04 |