反应详情

(2-(2-Morpholinoethylamino)-3-fluorophenyl)methanol (695 mg, 2.733 mmol) was stirred with MnO2 (966 mg, 11.11 mmol) in toluene (12 mL) at 115° C. for 2 days. The reaction was filtered through a plug of Celite with CH2Cl2 and the crude product was purified by ISCO chromatography eluting with EtOAc/Hex (12 g redisep column, 5-40% gradient over 30 CV) to give 2-(2-morpholinoethylamino)-3-fluorobenzaldehyde (495 mg). FIA: 253.17 (M+1)

1. filtrationThe reaction was filtered through a plug of Celite with CH2Cl2
2. customthe crude product was purified by ISCO chromatography
3. washeluting with EtOAc/Hex (12 g redisep column, 5-40% gradient over 30 CV)