HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-(2-Morpholinoethylamino)-3-fluorophenyl)methanol → 2-(2-Morpholinoethylamino)-3-fluorobenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-(2-Morpholinoethylamino)-3-fluorophenyl)methanol | HCID 57774478 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(2-Morpholinoethylamino)-3-fluorobenzaldehyde | HCID 57774415 | 71.8% |
Reaction Steps
(2-(2-Morpholinoethylamino)-3-fluorophenyl)methanol (695 mg, 2.733 mmol) was stirred with MnO2 (966 mg, 11.11 mmol) in toluene (12 mL) at 115° C. for 2 days. The reaction was filtered through a plug of Celite with CH2Cl2 and the crude product was purified by ISCO chromatography eluting with EtOAc/Hex (12 g redisep column, 5-40% gradient over 30 CV) to give 2-(2-morpholinoethylamino)-3-fluorobenzaldehyde (495 mg). FIA: 253.17 (M+1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163737B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-f01f0259b89b400580b0c56451809c13 |
| Source note | uspto-grants-2012_04 |