HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1696000Generated: November 2, 2026
Water → Methyl 4-benzyl-3-methylmorpholine-3-carboxylate
https://huagongshe.com/reaction/1696000
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Methyl 4-benzyl-3-methyl-5-oxomorpholine-3-carboxylate | HCID 67268468 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 4-benzyl-3-methylmorpholine-3-carboxylate | HCID 67268304 | — |
Reaction Steps
Dissolve methyl 4-benzyl-3-methyl-5-oxomorpholine-3-carboxylate in THF (10 volumes) and cool to 0° C. Add borane dimethylsulfide complex (1.5 eq) and allow to warm to room temperature. Add water (5 volumes) followed by EtOAc (10 volumes). Separate the organic layer, wash with saturated aqueous NaCl, dry over sodium sulfate, filtered, and concentrate to give methyl 4-benzyl-3-methylmorpholine-3-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08163755B2 |
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| Source dataset | uspto-grants-2012_04 |
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| ORD ID | ord-d21651bcb7a1415daf402a3a26ea931d |
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| Source note | uspto-grants-2012_04 |
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