反应详情

温度

0 °C

Dissolve methyl 4-benzyl-3-methyl-5-oxomorpholine-3-carboxylate in THF (10 volumes) and cool to 0° C. Add borane dimethylsulfide complex (1.5 eq) and allow to warm to room temperature. Add water (5 volumes) followed by EtOAc (10 volumes). Separate the organic layer, wash with saturated aqueous NaCl, dry over sodium sulfate, filtered, and concentrate to give methyl 4-benzyl-3-methylmorpholine-3-carboxylate.

1. temperatureto warm to room temperature
2. customSeparate the organic layer
3. washwash with saturated aqueous NaCl
4. dry with materialdry over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrate