反应详情

4-Chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile was treated with 2M NaOH solution (4 ml) in tetrahydrofuran (8 ml) at ambient temperature for 1 hour. The reaction mixture was cooled and was added water. The aqueous layer was extracted with EtOAc. And the organic layer was washed with brine, dried over MgSO4 and concentrated. Resultings were purified by silica gel column chromatography to give 4-chloro-1H-pyrrolo[2,3-b]-pyridine-3-carbonitrile as colorless powder.

1. temperatureThe reaction mixture was cooled
2. extractionThe aqueous layer was extracted with EtOAc
3. washAnd the organic layer was washed with brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated
6. customResultings were purified by silica gel column chromatography