Hydrochloric Acid → HCID 67277770, compound

HRID 1696229Notes

Reaction equation

HRID 1696229 reaction equation
[NH2:1][C:2]([C:4]1[C:5]([NH:13][C@@H:14]2[CH2:19][CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15]2)=[C:6]2[CH:12]=[CH:11][NH:10][C:7]2=[N:8][CH:9]=1)=[O:3].[ClH:27]>O1CCOCC1>[ClH:27].[NH:16]1[CH2:17][CH2:18][CH2:19][C@@H:14]([NH:13][C:5]2[C:4]([C:2]([NH2:1])=[O:3])=[CH:9][N:8]=[C:7]3[NH:10][CH:11]=[CH:12][C:6]=23)[CH2:15]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67278088HCID 67278088, compound

Product 1

HCID 67277770HCID 67277770, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of tert-butyl(3R)-3-{[5-(aminocarbonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]amino}-1-piperidinecarboxylate (125 mg) in dioxane (1.25 mL) was added 4M HCl in dioxane (1 ml) and the solution was stirred at ambient temperature for 2 hours. The reaction mixture was evaporated to give 4-[(3R)-3-piperidinylamino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrochloride (112 mg) as a white powder.

Workup

  1. customThe reaction mixture was evaporated

Sources & evidence

ORD record
ord-958573681e9946bd980402dc91653ece
Source dataset
uspto-grants-2012_04
Patent number
US08163767B2

Reaction notes

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