HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 58851616, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Pentanenitrile, 4,4-dimethyl-3-oxo- | HCID 108871 | — |
| Reactant | Acetic acid, 2-(3-hydrazinophenyl)-, ethyl ester | HCID 578094 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 58851616 | HCID 58851616 | 91.9% |
Reaction Steps
A solution of ethyl (3-hydrazinophenyl)acetate (15 g, 65 mmol) and 4,4-dimethyl-3-oxopentanenitrile (12.5 g, 0.1 mol) in EtOH (100 mL) containing conc. HCl (25 mL) was heated at reflux overnight. After removal of the solvent, the residue was washed with Et2O to afford ethyl 2-(3-(5-amino-3-t-butyl-1H-pyrazol-1-yl)phenyl)acetate (18 g). MS (ESI) m/z: 302 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163756B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-e580d72c24324adc8347a7ce41bf83c6 |
| Source note | uspto-grants-2012_04 |