HCID 67271028, compound → HCID 67271440, compound

HRID 1696442Notes

Reaction equation

HRID 1696442 reaction equation
[CH3:1][N:2]1[C:7]2[N:8]=[C:9](SC)[N:10]=[CH:11][C:6]=2[CH:5]=[C:4]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-:22])=[O:21])[CH:15]=2)[C:3]1=[O:23]>CCO.[Ni]>[CH3:1][N:2]1[C:7]2[N:8]=[CH:9][N:10]=[CH:11][C:6]=2[CH:5]=[C:4]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-:22])=[O:21])[CH:15]=2)[C:3]1=[O:23]

Participants

4

Reactant 1

HCID 67271028HCID 67271028, compound

Product 1

HCID 67271440HCID 67271440, compoundYield 41.3%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

To a solution of 8-methyl-2-(methylsulfanyl)-6-(3-nitrophenyl)-8H-pyrido[2,3-d]pyrimidin-7-one (1.0 g, 3 mmol) in EtOH (10 mL) was added Raney® nickel (5 g) and the mixture refluxed for 3 h. After cooling, the reaction was filtered and the filtrate concentrated to give 8-methyl-6-(3-nitrophenyl)-8H-pyrido[2,3-d]pyrimidin-7-one (0.35 g, 41% yield), which was used in the next reaction without further purification.

Workup

  1. temperaturethe mixture refluxed for 3 h
  2. temperatureAfter cooling
  3. filtrationthe reaction was filtered
  4. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-8eafa9c1e9c345abba9e487a0f46cd71
Source dataset
uspto-grants-2012_04
Patent number
US08163756B2

Reaction notes

Loading…