HCID 67271028, compound → HCID 67271440, compound

Participants

Reaction Steps

To a solution of 8-methyl-2-(methylsulfanyl)-6-(3-nitrophenyl)-8H-pyrido[2,3-d]pyrimidin-7-one (1.0 g, 3 mmol) in EtOH (10 mL) was added Raney® nickel (5 g) and the mixture refluxed for 3 h. After cooling, the reaction was filtered and the filtrate concentrated to give 8-methyl-6-(3-nitrophenyl)-8H-pyrido[2,3-d]pyrimidin-7-one (0.35 g, 41% yield), which was used in the next reaction without further purification.

Provenance & Evidence