Phosphorus oxychloride → HCID 178497361, compound

HRID 1696684Notes

Reaction equation

HRID 1696684 reaction equation
O[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][C:9]([C:11]([O:13][CH3:14])=[O:12])=[CH:10][C:4]=2[N:3]=1.P(Cl)(Cl)([Cl:17])=O>>[Cl:17][C:2]1[NH:6][C:5]2[CH:7]=[CH:8][C:9]([C:11]([O:13][CH3:14])=[O:12])=[CH:10][C:4]=2[N:3]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178497385HCID 178497385, compound

Product 1

HCID 178497361HCID 178497361, compound

Procedure

3.9 g of methyl 2-hydroxy-1H-benzimidazole-5-carboxylate and 50 ml of phosphorus oxychloride are stirred at 10° C. for 6 hours. The resulting thick slurry is, after cooling, stirred cautiously into 500 ml of ice-water, and the solid is filtered off with suction after one hour, washed with water and dried under reduced pressure.

Workup

  1. temperatureafter cooling
  2. filtrationthe solid is filtered off with suction after one hour
  3. washwashed with water
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-bd50ae98d8a84728becb215467c83343
Source dataset
uspto-grants-2012_04
Patent number
US08163774B2

Reaction notes

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