1,4-Dioxane hydrochloride → HCID 86643129, compound

HRID 1696700Notes

Reaction equation

HRID 1696700 reaction equation
Cl.O1CCOCC1.[CH3:8][N:9]([CH3:25])[C:10](=[S:24])[S:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[C:13]=1[O:20]COC>CO>[CH3:25][N:9]([CH3:8])[C:10](=[S:24])[S:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[C:13]=1[OH:20]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86643128HCID 86643128, compound

Product 1

HCID 86643129HCID 86643129, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4 N hydrogen chloride/dioxane solution (50 mL) was added to a methanol (200 mL) solution of the compound (70.49 g) synthesized in the above (2), and stirred at room temperature for 2 hours. The reaction liquid was concentrated and extracted with chloroform. The organic layer was washed with saturated saline, then dried with sodium sulfate, and concentrated to obtain the intended compound (46.65 g, 78%) as a brown solid.

Workup

  1. customThe reaction liquid
  2. concentrationwas concentrated
  3. extractionextracted with chloroform
  4. washThe organic layer was washed with saturated saline
  5. dry with materialdried with sodium sulfate
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-57d13a18444c467284999d559e082f2e
Source dataset
uspto-grants-2012_04
Patent number
US08163770B2

Reaction notes

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