1,4-Dioxane hydrochloride → HCID 86643129, compound

Participants

Reaction Steps

4 N hydrogen chloride/dioxane solution (50 mL) was added to a methanol (200 mL) solution of the compound (70.49 g) synthesized in the above (2), and stirred at room temperature for 2 hours. The reaction liquid was concentrated and extracted with chloroform. The organic layer was washed with saturated saline, then dried with sodium sulfate, and concentrated to obtain the intended compound (46.65 g, 78%) as a brown solid.

Provenance & Evidence