Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 1-{4-[(Triisopropylsilyl)oxy]phenyl}propan-1-one | HCID 15212280 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 67276684 | HCID 67276684 | — |
Reaction Steps
Titanium tetrachloride (28 mL) and morpholine (mL) were added in that order to a toluene (1.5 L) solution of 1-{4-[(triisopropylsilyl)oxy]phenyl}propan-1-one (130 g, 0.424 mol) synthesized in Reference Example 1-2-(1), and stirred at 130° C. for 12 hours. After cooled with ice, the insoluble matter in the reaction liquid was removed by filtration through Celite, and the mother liquid was concentrated to obtain a crude product (193 g) of the intended compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08163770B2 |
|---|
| Source dataset | uspto-grants-2012_04 |
|---|
| ORD ID | ord-bc533a3428e7474888d730c6bd007380 |
|---|
| Source note | uspto-grants-2012_04 |
|---|
