Ammonia → HCID 67274097, compound

HRID 1696727Notes

Reaction equation

HRID 1696727 reaction equation
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]2[S:6][C:7]([S:9](Cl)(=[O:11])=[O:10])=[CH:8][C:4]=2[CH:3]=1.[NH3:15]>C1COCC1>[Cl:1][C:2]1[CH:14]=[CH:13][C:5]2[S:6][C:7]([S:9]([NH2:15])(=[O:11])=[O:10])=[CH:8][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 151586055-Chloro-1-benzothiophene-2-sulfonyl chloride

Product 1

HCID 67274097HCID 67274097, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 5-chloro-benzo[b]thiophene-2-sulfonyl chloride (Komoriya, Satoshi; Haginoya, Noriyasu, Bioorganic & Medicinal Chemistry (2005), 13(12), 3927-3954; 0.57 g, 2.1 mmol) in THF (8.0 mL) was added ammonia gas until saturation at ca. 10° C., then the flask was stoppered, and the reaction mixture was stirred at rt for 4 h. The reaction mixture was then quenched with water; the organic solvent was slowly evaporated under vacuum. The precipitate formed was filtered off, washed with water and dried over P2O5 under high vacuum to obtain the desired compound (0.52 g) as a white solid.

Workup

  1. customThe reaction mixture was then quenched with water
  2. customthe organic solvent was slowly evaporated under vacuum
  3. customThe precipitate formed
  4. filtrationwas filtered off
  5. washwashed with water
  6. dry with materialdried over P2O5 under high vacuum

Sources & evidence

ORD record
ord-91c70284ca7e44458b07490c392162e8
Source dataset
uspto-grants-2012_04
Patent number
US08163778B2

Reaction notes

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