反应详情

温度

0 °C

To a solution of 0.089 g 5-methyl-thiophene-3-sulfonic acid amide in 4 ml acetonitrile was added at 0° C. 0.094 g phenylchloroformate and 0.127 g triethylamine. The mixture was stirred at 0° C. for 1 h. To the resulting suspension was added 0.127 g (6-amino-4-bromo-pyridin-2-yl)-urea and the mixture was heated to 60° C. for 18 h. The mixture was cooled to room temperature. The product was collected by filtration, washed with acetonitrile and dried to constant weight to yield 0.190 g of the title compound as white crystals.

1. temperaturethe mixture was heated to 60° C. for 18 h
2. temperatureThe mixture was cooled to room temperature
3. filtrationThe product was collected by filtration
4. washwashed with acetonitrile
5. customdried to constant weight