Ammonia → HCID 86630929, compound

HRID 1696740Notes

Reaction equation

HRID 1696740 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([S:8][CH3:9])[CH:5]=[C:4](Br)[N:3]=1.[NH3:11]>>[Br:1][C:2]1[N:3]=[C:4]([NH2:11])[CH:5]=[C:6]([S:8][CH3:9])[CH:7]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 54276775HCID 54276775, compound

Product 1

HCID 86630929HCID 86630929, compound

Conditions

Temperature
140 °C

Procedure

A mixture of 0.500 g 2,6-dibromo-4-methylsulfanyl-pyridine and 10 ml 25% aqueous ammonia was heated in an autoclave to 140° C. for 24 h. The solvent was evaporated and the residue was purified by chromatohraphy on silica gel with heptane:ethyl aceate=1:1 to yield 0.300 g of the title compound as white crystals. MS (ISP) M+H+=219.1; 221.1

Workup

  1. customThe solvent was evaporated
  2. customthe residue was purified by chromatohraphy on silica gel with heptane

Sources & evidence

ORD record
ord-de94b6d6c84b4b3cb31b5d608010cdee
Source dataset
uspto-grants-2012_04
Patent number
US08163778B2

Reaction notes

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