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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1696742Generated: November 2, 2026

Hydrogen Bromide → 4-trifluoromethyl-6-(4-trifluoromethylphenyl)-1H-pyridin-2-one

https://huagongshe.com/reaction/1696742

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrogen BromideHCID 260—
Reactant4-(Trifluoromethyl)-6-(4-trifluoromethylphenyl)-1,2-dihydro-2-oxopyridine-3-carbonitrileHCID 53256598—
SolventPropionic AcidHCID 1032—
Product4-trifluoromethyl-6-(4-trifluoromethylphenyl)-1H-pyridin-2-oneHCID 57468622136.9%

Reaction Steps

The compound was prepared from 2-oxo-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-1,2-dihydro-pyridine-3-carbonitrile (42 g, 126 mmol) and 48% aqueous HBr in propionic acid according to general procedure Ia, step 2 protocol b. Obtained as a white solid (52.98 g, 88%). MS (ISP) 308.3 [(M+H)+]; mp 203-204° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08163778B2
Source datasetuspto-grants-2012_04
ORD IDord-2ca8c6836e3640af9ddb148c92123f33
Source noteuspto-grants-2012_04