Phosphorus oxybromide → HCID 57468624, compound

HRID 1696743Notes

Reaction equation

HRID 1696743 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[NH:6][C:5](=O)[CH:4]=1.P(Br)(Br)([Br:24])=O>>[Br:24][C:5]1[CH:4]=[C:3]([C:2]([F:21])([F:20])[F:1])[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:6]=1

Participants

3

Reactant 2

HCID 24613Phosphorus oxybromideHCID 574686224-trifluoromethyl-6-(4-trifluoromethylphenyl)-1H-pyridin-2-one

Product 1

HCID 57468624HCID 57468624, compound

Procedure

The title compound was prepared from 4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one (example A.17 step 2) (15 g, 49 mmol) and phosphoryl bromide (42 g, 146 mmol) according to the general procedure Ia to d preparation of bromides. Obtained as a brown solid (18 g, quant.). MS (EI) 368.9 [(M)+] and 370.8 [(M+2)+]; mp 35-37° C.

Workup

  1. customObtained as a brown solid (18 g, quant.)

Sources & evidence

ORD record
ord-fa9b69a9301b43408ebc329e1b54a957
Source dataset
uspto-grants-2012_04
Patent number
US08163778B2

Reaction notes

Loading…