反应详情

A mixture of 2-bromo-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine (5.55 g, 15 mmol) and 4-methoxybenzylamine (5.9 mL, 45 mmol) in n-butanol (15 mL) was refluxed for 2 days. Evaporated to dryness, diluted with EtOAc, washed with 5% citric acid, sat. NaHCO3-sol. and brine, dried over Na2SO4. Removal of the solvent in vacuum left the title compound as an orange oil (6.409 g, 100%). MS (ISP) 427.3 [(M+H)+].

1. temperaturewas refluxed for 2 days
2. customEvaporated to dryness
3. additiondiluted with EtOAc
4. washwashed with 5% citric acid, sat. NaHCO3-sol
5. dry with materialand brine, dried over Na2SO4
6. customRemoval of the solvent in vacuum
7. waitleft the title compound as an orange oil (6.409 g, 100%)